Spatial trends of breast and prostate cancers in the United States between 2000 and 2005
© Mandal et al; licensee BioMed Central Ltd. 2009
Received: 30 May 2009
Accepted: 29 September 2009
Published: 29 September 2009
Breast cancer in females and prostate cancer in males are two of the most common cancers in the United States, and the literature suggests that they share similar features. However, it is unknown whether the occurrence of these two cancers at the county level in the United States is correlated. We analyzed Caucasian age-adjusted county level average annual incidence rates for breast and prostate cancers from the National Cancer Institute and State Cancer Registries to determine whether there was a spatial correlation between the two conditions and whether the two cancers had similar spatial patterns.
There was a significant correlation between breast and prostate cancers by county (r = 0.332, p < 0.001). This relationship was more pronounced when we performed a geographically-weighted regression (GWR) analysis (r = 0.552) adjusting for county unemployment rates. There was variation in the parameter estimates derived with the GWR; however, the majority of the estimates indicted a positive association. The strongest relationship between breast and prostate cancer was in the eastern parts of the Midwest and South, and the Southeastern U.S. We also observed a north-south pattern for both cancers with our cluster analyses. Clusters of counties with high cancer incidence rates were more frequently found in the North and clusters of counties with low incidence rates were predominantly in the South.
Our analyses suggest breast and prostate cancers cluster spatially. This finding corroborates other studies that have found these two cancers share similar risk factors. The north-south distribution observed for both cancers warrants further research to determine what is driving this spatial pattern.
An extensive review by López-otín and Diamandis compared breast and prostate cancers and highlighted several similar features and characteristics . One of the most obvious similarities between breast and prostate cancers is their hormonal regulation. At least some breast and prostate cancer cell types appear to have receptors for a number of the same steroid hormones (e.g. estrogens, progesterone, and androgens) and growth hormones, such as androgen-induced growth factor and keratinocyte growth factor. The negative impact of high levels of endogenous sex steroids, and the benefit of low circulating sex steroids for both breast and prostate cancers is well documented in the literature [5, 6], and suggests that exposure to exogenous hormones (i.e. hormone therapy, contraceptives, dietary fats, and environmental endocrine disruptors) may also have a negative impact on the onset and progression of these diseases. In fact, anti-estrogens and anti-androgens are sometimes effective treatments for breast and prostate cancers, respectively .
The patho-physiological mechanisms by which breast and prostate tumors develop is not well understood, but evidence suggests several independent pathways may exist, involving different receptors and complex cascades of events that ultimately culminate in abnormal cell proliferation. Most often tumors of the breast and prostate involve epithelial cell types and express similar biochemical markers, which suggests analogous patho-physiologies . At least one of these common biomarkers-prostate specific antigen-has been detected in breast and prostate tumors, and in no other tumors .
Some of the main gene alterations associated with breast cancer (e.g. BRCA1 and BRCA2) have also been found in some individuals with prostate cancer , and the most commonly identified gene alteration in prostate cancer patients (e.g. alterations in the AR gene) has been detected in breast cancer patients . The similarity in the genetic component of these two cancers suggests they share similar patho-physiological mechanisms. Another link between these two cancers is the epidemiological studies, which suggest individuals from families with a high incidence of breast cancer are more likely to develop prostate cancer and vice versa . Interestingly, genetics accounts for about 5% of both breast and prostate cancer cases .
Epidemiological studies have also identified similar protective factors for both breast and prostate cancers. In the last 17 years vitamin D has received a great deal of attention as an important compound for both breast and prostate cancer prevention [13–16]. It is suggested that the active form of vitamin D, 1,25(OH)2D regulates transcription in cells with vitamin D receptors including breast and prostate cells .
These two types of cancers share many similarities, but their spatial distributions have not been compared. If they are homologous cancers they should occur in similar areas at similar rates. The objective of our study was to determine whether these two cancers are spatially correlated.
Breast cancer clusters
"Cold" clusters (or areas where the incidence of breast cancer was relatively low) occurred predominantly in the South (Figure 2). There was only one small cold cluster in the northern Midwest (Figure 2).
Prostate cancer clusters
There was a large area where counties had a lower incidence of prostate cancer than expected. This area spanned the southern part of the Midwest and northern part of the South and Southeast regions (Figure 3). There were small to medium-sized cold clusters that also occurred in the southern parts of the Mountain West and South regions.
For the most part there was a north-south distribution to both types of cancers; however, the hot and cold clusters for these cancers did not always overlap. Shared geographic clusters with high incidence rates of breast and prostate cancers occurred in the Northeast and Midwest (Figures 2 and 3). Common areas of cold clusters for both cancers were found in the South, parts of the Southeast region, and southern parts of the Mountain West region (Figures 2 and 3). The north-south distribution for both cancers was observed regardless of the band distance used in the Getis-Ord Gi* cluster analysis.
Correlation coefficients for regression analyses between different types of cancers.
Number of counties
Caucasians & Hispanics
The correlation coefficient from the unemployment-adjusted geographically-weighted regression (GWR) analysis for breast and prostate cancer incidence rates for Caucasians was 0.552, which suggests a stronger correlation between the two cancers when information from the surrounding counties was taken into account. There were only 26 out of 2651 (1.0%) counties that had standardized residuals greater than or less than 3 standard deviations from the mean. This was only slightly above what is expected from normal variation suggesting the regression model fit the data well. Further, the counties with these more extreme residual values appeared to be dispersed at random throughout the U.S.
We determined, using county-level data from the NCI, that the annual age-adjusted incidence rates of breast and prostate cancer in the U.S. between 2000/2001 and 2004/2005 were correlated at the county level (Table 1 and Figure 4). In general, counties with a high incidence of breast cancer also had a high incidence of prostate cancer, and vice versa. The correlation coefficient between these two cancers was greater than the correlation coefficient between these cancers and other cancers that are not hormonally regulated (Table 1), suggesting that risk factors for both breast and prostate cancers either cluster together spatially or the two cancers share common risk factors.
The correlation between these cancers increased from 0.332 to 0.552 when we used a geographically-weighted regression model, which accounted for data within a 200 km radius. This sudden increase in the correlation coefficient suggests similar risk factors for these cancers at a geographical area greater than the county level. These results also suggest our county level correlation is unlikely to be due to the county's cancer detection and reporting system.
The parameter estimates calculated for each county in our geographically-weighted regression model indicated over 76% of the counties had a significant positive association between breast and prostate cancer. This relationship varied across the U.S. and was strongest in the eastern area of the Midwest and adjacent areas of the Southeast and Southern U.S (Figure 4). The areas, where the standardized parameter estimates were the highest, were often where the hot and cold clusters for breast and prostate cancers overlapped (Figures 2, 3, and 4). There were only a few areas where the parameter estimates suggested a negative correlation between breast and prostate cancer, and these values were not statistically significant (i.e. blue areas in Figure 4). For the most part, our data suggested the rates for both of these cancers were positively correlated. This study identifies counties, as well as larger geographic areas within the U.S. where this correlation is strongest and weakest, which is useful for further research into potential factors driving the incidence of these cancers.
Both cancers also had a distinct north-south distribution (Figures 2 and 3), with the exception of the area known as "cancer alley" in the states of Louisiana and Mississippi . In general, areas with higher than expected incidence of cancer (hot clusters) were located in the northern states and areas with lower than expected incidence of cancer (cold clusters) were in the southern states. This trend has also been reported by Schwartz and Hanchette  for prostate cancer mortality rates in the U.S. A U.S.-wide spatial analysis has not been reported for breast cancer; however, there have been reports of higher occurrence of breast cancer mortality in the northeastern U.S. than the southeastern part of the country [20, 21].
There are several possible explanations for the north-south pattern of breast and prostate cancers. One explanation proposed by several researchers is the low exposure to ultraviolet radiation (UV) in the northern states, especially during the winter months [19, 22], which is believed to result in lower vitamin D levels . There are several independent researchers who have experimentally documented the beneficial effects of vitamin D on differentiation and proliferation for cell types with vitamin D receptors such as prostate and breast cells [23, 24]. There are also several epidemiological studies that have examined UV exposure as a modifying factor for breast and prostate cancers and found a protective effect [19, 24].
Another risk factor that may contribute to the clustering of cancer in the North may be low temperature, which almost always confounds UV exposure. That is, areas with a high UV index generally have high temperature and those with a low UV index have lower temperature. Temperature has a significant effect on ecological processes. Experiments have demonstrated that the biodegradation of certain organic compounds, including endocrine disruptors and chelation of heavy metals, is temperature-dependant and slower at colder temperatures [25, 26]. It is also documented that semi-volatile organic chemicals (i.e. PCBs) precipitate out of the atmosphere more efficiently at cold temperatures and during snow events [27–32]. There may, therefore, be an interaction between precipitation, temperature, and atmospheric pollution, and exposure to endocrine disruptors, which have been associated with an increase in risk of both breast and prostate cancer [6, 33, 34], may be greater at higher altitudes and latitudes. This phenomenon would occur on a global scale and may explain the higher incidence of cancers at higher latitudes that have been reported in numerous countries .
There are also other differences in the distribution of risk and protective factors across the U.S. that may partially explain the north-south distribution of cancer observed in this study. For example, cultural differences that increase or decrease the risk of cancer (i.e. behavior and diets) may be unevenly distributed between the northern and southern U.S. It is also possible that the rate of other diseases, such as cardiovascular disease, is higher in the southern U.S.  thereby resulting in premature mortality and lower incidence of cancer in these areas. Because this study was an ecological study and data were obtained at the county level, we could not adjust for differences in individual risk factors. However, we were able to adjust for age and race by using Caucasians only and age-adjusted rates in our analyses. So it is unlikely that age and race played a significant role in the distribution pattern observed.
Ethnicity may have contributed to the distribution pattern as we could not obtain data on Caucasians that were not of Hispanic origin. Because individuals of Hispanic origin have lower risks of breast and prostate cancers , and the distribution of individuals that are of Hispanic origin is not even throughout the continental U.S., this factor may have contributed to the north-south distribution pattern. However, it is unlikely that this factor was the only reason for the north-south distribution because other researchers have noted a similar pattern in other countries .
Socioeconomic status is a known risk factor for many cancers and their outcome. To minimize the effect of this variable on our outcome of interest we used incidence data instead of mortality data. Although socioeconomic status is associated with the detection of cancer, it is most likely less dependent on the availability of adequate health care than mortality rates, which is strongly influenced by the treatment received by the patient. We also corrected for this variable in our GWR model by including the county's average annual unemployment rate between 2001 and 2004. Despite this, it is still possible that this parameter biased the findings of the correlation and influenced the cluster analyses. However, the fact that other types of cancers were not as strongly correlated with breast and prostate cancers at the county level (Table 1) suggests breast and prostate cancers are correlated (i.e. counties with high incidence rates of breast cancer also tend to have a high incidence rate of prostate cancer and vice versa) regardless of the effect of socioeconomic status.
One other possible bias in this study was the disparity in the size of the counties within the continental U.S. In general, the counties in the east were much smaller than those in the west, which may have affected our cluster analyses. Because the predominant pattern observed was north to south, and this pattern was consistent using different distances to measure clusters (data not shown), we felt that the east to west variation in the size of individual counties most likely did not affect our overall conclusions. Further, the north-south disease pattern observed in this study is consistent with other research that has found a relationship between latitude and breast and prostate cancers in other areas of the world .
There were a few inconsistencies in the spatial distribution and correlation between breast and prostate cancers. For example, there was a small cluster of counties in the south known as "cancer alley" that had a high incidence of prostate cancer, but did not have higher than expected breast cancer rates. Similarly, there were a few clusters of counties with a high incidence of breast cancer in the southeast that did not coincide with elevated prostate cancer (Figure 2 and 3). The variation in the parameter estimates from our GWR analysis also suggests the relationship between these cancers varies and, therefore they may not be completely homologous. If we had refined our case definition and only included specific types of breast or prostate cancers that are more likely to be analogous (i.e. similar cell types and responsive to specific types of steroid hormones), the distribution may have overlapped better. Further, the aggregation of data at the county level renders it impossible to analyze information at a smaller spatial scale. The reason we used county level data is because it was age-adjusted, averaged over several years, and readily available for the entire U.S.
There are multiple factors that may act synergistically on prostate and breast cell types, while others may act antagonistically on these tissues [4, 6], which may account for some of the inconsistencies in the distribution of the two types of cancers. Risk factors for these cancers may also not be equally distributed within the male and female populations in a county. Despite the differences in the distribution of these cancers, the distinct north-south spatial pattern and the positive correlation between the cancers warrants further investigation to identify the factors driving these patterns. A model that includes variables such as socioeconomic status, incidence of other diseases, temperature, precipitation, pollution and UV indices, and controls for ethnicity would provide insight into the epidemiology of breast and prostate cancers. The findings of this study add to the growing evidence in the literature that prostate and breast cancers have similar risk factors and patho-physiological mechanisms.
Spatial cluster analyses for individual cancers
We extracted age-adjusted (to the 2000 U.S. standard population) annual incidence rates (cases per 100,000 population per year) for breast and prostate cancer between 2000 and 2004 or 2001 and 2005 from the National Cancer Institute (NCI) website , for each county in the United States for Caucasians and Caucasians of Hispanic origin. All data from the NCI website originate from individual State Cancer Registries. Analyses were only performed on data for Caucasians (of Hispanic and non-Hispanic origin combined) with the exception of data from counties in Illinois. The data for this state were only available for all races combined; therefore, we only included the data from counties where more than 95% of the population was Caucasian. We assumed the rates were representative of Caucasians in these cases. Rates for prostate and breast cancer were only for invasive cancers (not in situ). We excluded counties with average annual counts of less than 3-5 from the analysis because stable accurate age-adjusted rates were not available for these counties.
For six states, including Illinois (2001-2005), Maryland (2000), Minnesota (2000-2004), Mississippi (2003-2005), Tennessee (1999-2003) and Virginia (2000-2004), we obtained data from individual State Cancer Registry websites, as their data were not available through the NCI. The time block used to calculate the average annual age-adjusted incidence rate varied slightly by states (i.e. 2000-2004 or 2001-2005, and in one case 1999-2003).
We assessed the cancer data from the continental United States for spatial clustering using the Getis-Ord Gi* ArcGIS (v 9.3). All counties with missing data were removed for this analysis. We used the fixed distance band of 200 km in the Getis-Ord Gi* cluster analysis for breast and prostate cancers. This distance was selected based on the autocorrelation detected using a semivariance analysis  (data not shown) and the Getis-Ord Gi* analysis algorithm criterion of at least 1 county and preferably 8-10 counties for reliable results. All counties with significant Z scores (e.g. values ≥ 1.96 and ≤ -1.96) were identified. Negative values represented counties where there were 200 km radius clusters of lower than expected cancer incidence rates and high Z scores indicated counties where there were higher than expected cancer incidence rates within a 200 km radius. We also ran the Getis-Ord Gi* analysis using a distance band of 300 km and 400 km for comparison. We used the regions of the U.S. depicted in Figure 2 to describe the cluster patterns. All maps were generated in ArcGIS (v 9.3).
Spatial correlation between breast and prostate cancer
Two methods were used to assess the spatial correlation between the incidence rates of breast and prostate cancers. First, we used an ordinary least square regression model to determine if there was a correlation between breast and prostate cancers at the county level. Second, we used a geographically-weighted regression analysis to determine if there was correlation between the incidence rates of these two cancers at the county level after adjusting for local, spatially-structured variation.
Ordinary least square regression analyses (OLS)
We used the dataset described above to assess whether counties with a high incidence of breast cancer also had a high incidence of prostate cancer and vice versa. The regression analyses were conducted in Minitab (v 15.1). Assumptions of parametric tests were tested using regression diagnostics.
For comparison, correlations between these two cancers and lung and bronchial, colon and rectal, ovarian, and testicular cancers were also calculated. The data on these cancers were extracted in a similar manner with the exception that all races were included in the calculations and the seven states that did not provide data to the NCI were excluded. To ensure an appropriate comparison we also extracted breast and prostate cancer incidence rates from these same states for all races. Regression analyses were conducted as described above.
Geographically-weighted regression analyses (GWR)
We tested for and found spatial autocorrelation in the incidence of breast and prostate cancers among counties using a semivariance analysis , and concluded that incidence rates in nearby counties were more likely to be similar than among counties separated by greater distances. Our Getis-Ord Gi* cluster analyses also supported this finding. To evaluate the correlation between breast and prostate cancers accounting for data in surrounding counties, we conducted a geographically-weighted regression analysis using ArcGIS (v 9.3)  adjusting for county average annual unemployment rates between 2001 and 2004. The unemployment rates were obtained from the United States Department of Agriculture Economic Research Service . Specifically, a fixed kernel type function with a 200 km bandwidth parameter was used to calculate the GWR regression coefficients. Standardized residuals greater than 3 standard deviations above and below the mean were identified. The parameter estimates, derived for each county were divided by their standard errors, creating standardized t statistics. These values were mapped in ArcGIS (v 9.3). The analysis was done using the same dataset used for the spatial clustering analysis on Caucasians, which included individuals of Hispanic origin.
We would like to thank the reviewers for their suggestions on this manuscript. Their insight on the results of the geographically-weighted regression analysis was most helpful.
- Catalona WJ, Smith DS, Ratliff TL, Dodds KM, Coplen DE, Yuan JJ, Petros JA, Andriole GL: Measurement of prostate-specific antigen in serum as a screening test for prostate cancer. N Engl J Med. 1991, 324 (17): 1156-1161. 10.1056/NEJM199104253241702.PubMedView ArticleGoogle Scholar
- United States Cancer Statistics: 2004 Incidence and Mortality. 2007, Atlanta: U.S. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer InstituteGoogle Scholar
- National Cancer Institute-State Cancer Profiles.http://statecancerprofiles.cancer.gov/incidencerates/
- Lopez-Otin C, Diamandis EP: Breast and prostate cancer: an analysis of common epidemiological, genetic, and biochemical features. Endocr Rev. 1998, 19 (4): 365-396. 10.1210/er.19.4.365.PubMedGoogle Scholar
- Cuzick J: Hormone replacement therapy and the risk of breast cancer. Eur J Cancer. 2008, 44 (16): 2344-2349. 10.1016/j.ejca.2008.07.041.PubMedView ArticleGoogle Scholar
- Prins GS: Endocrine disruptors and prostate cancer risk. Endocr Relat Cancer. 2008, 15 (3): 649-656. 10.1677/ERC-08-0043.PubMedPubMed CentralView ArticleGoogle Scholar
- Osborne M, Boyle P, Lipkin M: Cancer prevention. Lancet. 1997, 349 (Suppl 2): SII27-30.PubMedView ArticleGoogle Scholar
- Diamandis EP, Yu H: Nonprostatic sources of prostate-specific antigen. Urol Clin North Am. 1997, 24 (2): 275-282. 10.1016/S0094-0143(05)70373-6.PubMedView ArticleGoogle Scholar
- Struewing JP, Hartge P, Wacholder S, Baker SM, Berlin M, McAdams M, Timmerman MM, Brody LC, Tucker MA: The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med. 1997, 336 (20): 1401-1408. 10.1056/NEJM199705153362001.PubMedView ArticleGoogle Scholar
- Wooster R, Mangion J, Eeles R, Smith S, Dowsett M, Averill D, Barrett-Lee P, Easton DF, Ponder BA, Stratton MR: A germline mutation in the androgen receptor gene in two brothers with breast cancer and Reifenstein syndrome. Nat Genet. 1992, 2 (2): 132-134. 10.1038/ng1092-132.PubMedView ArticleGoogle Scholar
- Valeri A, Fournier G, Morin V, Morin JF, Drelon E, Mangin P, Teillac P, Berthon P, Cussenot O: Early onset and familial predisposition to prostate cancer significantly enhance the probability for breast cancer in first degree relatives. Int J Cancer. 2000, 86 (6): 883-887. 10.1002/(SICI)1097-0215(20000615)86:6<883::AID-IJC20>3.0.CO;2-F.PubMedView ArticleGoogle Scholar
- Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, Collins N, Gregory S, Gumbs C, Micklem G: Identification of the breast cancer susceptibility gene BRCA2. Nature. 1995, 378 (6559): 789-792. 10.1038/378789a0.PubMedView ArticleGoogle Scholar
- Hanchette CL, Schwartz GG: Geographic patterns of prostate cancer mortality. Evidence for a protective effect of ultraviolet radiation. Cancer. 1992, 70 (12): 2861-2869. 10.1002/1097-0142(19921215)70:12<2861::AID-CNCR2820701224>3.0.CO;2-G.PubMedView ArticleGoogle Scholar
- John EM, Schwartz GG, Dreon DM, Koo J: Vitamin D and breast cancer risk: the NHANES I Epidemiologic follow-up study, 1971-1975 to 1992. National Health and Nutrition Examination Survey. Cancer Epidemiol Biomarkers Prev. 1999, 8 (5): 399-406.PubMedGoogle Scholar
- Boscoe FP, Schymura MJ: Solar ultraviolet-B exposure and cancer incidence and mortality in the United States, 1993-2002. BMC Cancer. 2006, 6: 264-10.1186/1471-2407-6-264.PubMedPubMed CentralView ArticleGoogle Scholar
- John EM, Koo J, Schwartz GG: Sun exposure and prostate cancer risk: evidence for a protective effect of early-life exposure. Cancer Epidemiol Biomarkers Prev. 2007, 16 (6): 1283-1286. 10.1158/1055-9965.EPI-06-1053.PubMedView ArticleGoogle Scholar
- DeLuca HF: Evolution of our understanding of vitamin D. Nutr Rev. 2008, 66 (10 Suppl 2): S73-87. 10.1111/j.1753-4887.2008.00105.x.PubMedView ArticleGoogle Scholar
- U.S. Environmental Protection Agency.http://www.epa.gov/TRI/guide_docs/pdf/2003/2003_datausepaper.pdf
- Schwartz GG, Hanchette CL: UV, latitude, and spatial trends in prostate cancer mortality: all sunlight is not the same (United States). Cancer Causes Control. 2006, 17 (8): 1091-1101. 10.1007/s10552-006-0050-6.PubMedView ArticleGoogle Scholar
- Blot WJ, Fraumeni JF, Stone BJ: Geographic patterns of breast cancer in the United States. J Natl Cancer Inst. 1977, 59 (5): 1407-1411.PubMedGoogle Scholar
- Sturgeon SR, Schairer C, Gail M, McAdams M, Brinton LA, Hoover RN: Geographic variation in mortality from breast cancer among white women in the United States. J Natl Cancer Inst. 1995, 87 (24): 1846-1853. 10.1093/jnci/87.24.1846.PubMedView ArticleGoogle Scholar
- John EM, Schwartz GG, Koo J, Wang W, Ingles SA: Sun exposure, vitamin D receptor gene polymorphisms, and breast cancer risk in a multiethnic population. Am J Epidemiol. 2007, 166 (12): 1409-1419. 10.1093/aje/kwm259.PubMedView ArticleGoogle Scholar
- Schwartz GG: Vitamin D and the epidemiology of prostate cancer. Semin Dial. 2005, 18 (4): 276-289. 10.1111/j.1525-139X.2005.18403.x.PubMedView ArticleGoogle Scholar
- Rhee van der HJ, de Vries E, Coebergh JW: Does sunlight prevent cancer? A systematic review. Eur J Cancer. 2006, 42 (14): 2222-2232. 10.1016/j.ejca.2006.02.024.PubMedView ArticleGoogle Scholar
- Giese C, Miethe N, Schlenker G: [Biodegradation of estrogens in stream water]. Berl Munch Tierarztl Wochenschr. 2007, 120 (3-4): 141-147.PubMedGoogle Scholar
- Sanscartier D, Zeeb B, Koch I, Reimer K: Bioremediation of diesel-contaminated soil by heated and humidified biopile system in cold climates. Cold Regions Science and Technology. 2009, 55 (1): 167-173. 10.1016/j.coldregions.2008.07.004.View ArticleGoogle Scholar
- Wania F, Westgate JN: On the mechanism of mountain cold-trapping of organic chemicals. Environ Sci Technol. 2008, 42 (24): 9092-9098. 10.1021/es8013198.PubMedView ArticleGoogle Scholar
- Franz TP, Eisenreich SJ: Snow scavenging of polychlorinated biphenyls and polycyclic aromatic hydrocarbons in Minnesota. Environ Sci Technol. 1998, 32 (12): 1771-1778. 10.1021/es970601z.View ArticleGoogle Scholar
- Calamari D, Bacci E, Focardi S, Gaggi C, Morosini M, Vighi M: Role of plant biomass in the global environmental partitioning of chlorinated hydrocarbons. Environ Sci Technol. 1991, 25: 1489-1495. 10.1021/es00020a020.View ArticleGoogle Scholar
- Wania F, Mackay D: Tracking the distribution of persistent organic pollutants. Environ Sci Technol. 1996, 30 (9): A390-A396.View ArticleGoogle Scholar
- Simonich SL, Hites RA: Global distribution of persistent organochlorine compounds. Science. 1995, 269 (5232): 1851-1854. 10.1126/science.7569923.PubMedView ArticleGoogle Scholar
- Franz TP, Eisenreich SJ: Snow scavenging of polychlorinated biphenyls and polycyclic aromatic hydrocarbons in Minnesota. Environ Sci Technol. 1998, 32 (12): 1771-1778. 10.1021/es970601z.View ArticleGoogle Scholar
- Brisken C: Endocrine disruptors and breast cancer. Chimia. 2008, 62 (5): 406-409. 10.2533/chimia.2008.406.View ArticleGoogle Scholar
- Laden F, Hunter DJ: Environmental risk factors and female breast cancer. Annu Rev Public Health. 1998, 19: 101-123. 10.1146/annurev.publhealth.19.1.101.PubMedView ArticleGoogle Scholar
- Centers for Disease Control and Prevention, Department of Health and Human Services.http://www.cdc.gov/DHDSP/library/maps/index.htm
- Fortin M-J, Mark D: Spatial analysis-a guide for ecologists. 2005, Cambridge University PressGoogle Scholar
- Rangel T, Diniz-Filho JA, Bini LM: Towards an integrated computational tool for spatial analysis in macroecology and biogeography. Global Ecology and Biogeography. 2006, 15 (4): 321-327. 10.1111/j.1466-822X.2006.00237.x.View ArticleGoogle Scholar
- United States Department of Agriculture Economic Research Service.http://www.ers.usda.gov/
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.