Health Areas With Most Extreme Incidence Residuals Of CD (1995 - 2000). Health areas in Quebec with largest residuals according to a regression model accounting for known regional risk factors. Residual values were smoothed using an empirical Bayes (EBS) method. EBS-residuals larger and smaller than two standard deviations from the mean (zero) were tagged as "largest residuals". Areas in green reflect locations of largest residuals corresponding to an overestimation of the statistical model and areas in grey reveal locations of largest residuals corresponding to an underestimation of the model.