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Table 2 Multi-level random effects logistic regression model of individual and area-level factors associated with aggressive histological grade at diagnosis for breast cancer among white and black women in Maryland, 1992–2003 (34,310 women in 3568 census blockgroups, Maryland cancer registry)

From: The association of area-level social class and tobacco use with adverse breast cancer characteristics among white and black women: evidence from Maryland, 1992–2003

  Model 1 Model 2 Model 3 Model 4 Model 5
Fixed Effects O.R. 95% CI O.R. 95% CI O.R. 95% CI O.R. 95% CI O.R. 95% CI
Intercept 0.71 (0.70,0.74) 0.72 (0.70,0.74) 0.72 (0.70,0.74) 0.64 (0.56,0.73) 0.63 (0.53,0.71)
Individual Level           
Age 0.98 (0.98,0.98) 0.98 (0.98,0.98) 0.98 (0.98,0.98) 0.98 (0.98,0.98) 0.98 (0.98,0.98)
Black Race 1.69 (1.60,1.78) 1.65 (1.56,1.74) 1.69 (1.59,1.79) 1.73 (1.62,1.85) 1.71 (1.59,1.83)
Year of Diagnosis 0.95 (0.95,0.96) 0.96 (0.95,0.96) 0.96 (0.95,0.96) 0.96 (0.95,0.96) 0.96 (0.95,0.96)
Census Blockgroup Level           
Social Class    0.96 (0.94,0.99) 0.94 (0.92,0.97) 0.96 (0.93,0.99) 0.97 (0.93,1.00)
Class*Black Race      1.08 (1.03,1.15) 1.06 (1.01.1.13) 1.06 (0.99,1.12)
Tobacco Spending (per $100)        1.01 (1.00,1.03) 1.02 (1.00,1.04)
Tobacco*Black Race          0.98 (0.94,1.02)
Random Effects Estimate P Value Estimate P Value Estimate P Value Estimate P Value Estimate P Value
Blockgroup Level Variance 0.01685 <0.0001 0.01505 <0.0001 0.01505 <0.0001 0.01421 <0.0001 0.01422 <0.0001
Residual ICC 0.00486 0.04 0.00456 0.05 0.00456 0.05 0.00430 0.06 0.00431 0.06
  1. Among women with a histological grade of tumor reported, those with grades 3 or 4, compared to those with grades 1 or 2.
  2. Age in years, centered at the median age of 59. Year of Diagnosis is centered at 1997.
  3. Census blockgroup social class index standardized by subtracting median (272), dividing by the standard deviation (37.7).
  4. Census blockgroup estimated tobacco spending is average per household, in units of $100, and is centered at median (7).
  5. Significance of variance of the blockgroup-level random intercept calculated with the Wald X 2 test.
  6. Significance of the residual intraclass (within blockgroup) correlation based on the likelihood ratio X 2 test.